Ecuador's President Lenin Moreno said he would “not negotiate with criminals.”
Mr Moreno said he would not have to give up his decision to scrap fuel subsidies.
Chairing a meeting cabinet, the president said he would not bow to the demands of “criminals”.
Angered by the rising cost of fuel, protesters have taken over the streets of the country. 19659002] On Thursday, when the cuts came into effect, protesters blocked roads across the county, bringing transportation to a standstill
In response, a 60-day state of emergency was declared by Mr Moreno, who said he would not allow protesters to “impose chaos”
More protests were held on Friday in Quito, the capital, and the city of Guayaquil, where roads were strewn with makeshift barricades and burning tyres.
Around 350 people were arrested during the demonstrations, Ecuador's interior ministry said, with reports of looting and clashes with police.
Authorities said 28 police officers have been hurt, a dozen police cars destroyed, and a local government building attack.
What did President Moreno say?
At a meeting cabinet on Friday, President Moreno said he would be open to talks with anyone affected by the cuts, but dismissed those who have resorted to violence
“We do not negotiate with criminals,” the 66-year-old president, who took office in 2017, said.
Striking a defiant tone, Mr Moreno said the majority of Ecuadorians supported his “brave decision “
” “I am very happy about the massive response, in its majority, we have received from Ecuador's people to support a brave decision taken by the national government,” Mr Moreno said.
Mr Moreno said the fuel subsidies, which cost the government $ 1.3bn (£ 1bn)
The Elimination of the Fuel Subsidies, introduced in the 1970s, are part of Mr Moreno's plan to shore up Ecuador's flagging economy and ease its debt burden.
Ecuador's government has agreed to share a loan with the International Monetary Fund (IMF).
The agreement, signed in March, allows Ecuador to borrow $ 4.2bn (£ 3.4bn).
On Tuesday, Ecuador announced it was leaving the Organization of the Petroleum Exporting Countries (Opec) to pump more oil and raise revenues.